Recombinant Human Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)

• Purity: >85% (SDS-PAGE)
• Host Species: Homo sapiens (Human)
• Accession: P49354
• Gene: FNTA
• CAT.NO: B000301
• Expression Systems: E.coli In Vivo Biotinylation in E.coli Yeast Baculovirus Mammalian cell
• Product Name: Recombinant Human Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)
• Source: E.coli;In Vivo Biotinylation in E.coli;Yeast;Baculovirus;Mammalian cell
• Protein Expression Range: 2-379
• Tag: Tag type will be determined during the manufacturing process.
• Form: Lyophilized powder
• Buffer: Tris/PBS-based buffer, 6% Trehalose.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Alternative Names: CAAX farnesyltransferase alpha subunit; CAAX farnesyltransferase subunit alpha; EC 2.5.1.58; EC 2.5.1.59; Farnesyl protein transferase alpha subunit; Farnesyltransferase CAAX box alpha; Farnesyltransferase; CAAX box; alpha; Fnta; FNTA_HUMAN; FPTA; FTase alpha; FTase-alpha; GGTase I alpha; GGTase-I-alpha; MGC99680; OTTHUMP00000229206; OTTHUMP00000229262; PGGT1A; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Protein prenyltransferase alpha subunit repeat containing 2; PTAR2; Ras proteins prenyltransferase alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha
• Target Protein Sequence: AATEGVGEA AQGGEPGQPA QPPPQPHPPP PQQQHKEEMA AEAGEAVASP MDDGFVSLDS PSYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSDKFRDVY DYFRAVLQRD ERSERAFKLT RDAIELNAAN YTVWHFRRVL LKSLQKDLHE EMNYITAIIE EQPKNYQVWH HRRVLVEWLR DPSQELEFIA DILNQDAKNY HAWQHRQWVI QEFKLWDNEL QYVDQLLKED VRNNSVWNQR YFVISNTTGY NDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS KYPNLLNQLL DLQPSHSSPY LIAFLVDIYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG RSLQSKHSTE NDSPTNVQQ
• Protein Length: Full Length of Mature Protein
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

This essential subunit is a critical component of both the farnesyltransferase and geranylgeranyltransferase complexes. It aids in the transfer of a farnesyl or geranylgeranyl group from farnesyl or geranylgeranyl diphosphate to a cysteine residue located four positions from the C-terminus of proteins with the C-terminal sequence Cys-aliphatic-aliphatic-X. Additionally, it may play a role in positively regulating neuromuscular junction development by acting downstream of MUSK, primarily through its involvement in the prenylation and activation of RAC1. This process contributes to the proper function and signaling at the neuromuscular junction.