This enzyme exhibits both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity, with a preference for tri-alpha-glutamate peptides. In the intestine, it is essential for folate uptake, supporting nutrient absorption. In the brain, it regulates excitatory neurotransmission by hydrolyzing the neuropeptide N-acetylaspartylglutamate (NAAG), releasing glutamate and influencing synaptic activity.
The enzyme is also implicated in prostate tumor progression, highlighting its potential role in cancer biology. Additionally, it displays dipeptidyl-peptidase IV-like activity and, in vitro, can cleave Gly-Pro-AMC. These multifunctional properties make it a significant factor in metabolic processes, neural signaling, and disease progression, underscoring its importance in both physiological and pathological contexts.
| Product Name | Recombinant Human PSMA Protein (N-6His) |
| Accession | Q04609 |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Host Species | Human |
| Gene | PSMA |
| Source | Human Cells |
| Protein Expression Range | Lys44-Ala750 |
| Tag | N-6His |
| Molecular Mass | 80.6 KDa |
| Buffer | Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 5% Trehalose, pH 5.5. |
| Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
