ROS1 is a receptor tyrosine kinase (RTK) involved in epithelial cell differentiation and the regionalization of the proximal epididymal epithelium. Its endogenous ligand, NELL2, stimulates ROS1, activating intracellular signaling pathways essential for epididymal epithelial differentiation and sperm maturation.
ROS1 may regulate multiple downstream signaling cascades associated with cell differentiation, proliferation, growth, and survival, including the PI3K-mTOR pathway. It mediates phosphorylation of PTPN11, a key activator of this pathway, and may also phosphorylate and activate the transcription factor STAT3, promoting anchorage-independent cell growth. Additionally, ROS1 phosphorylates and activates VAV3, a guanine nucleotide exchange factor crucial for cell morphology regulation.
Other downstream signaling proteins influenced by ROS1 activation include AKT1, MAPK1, MAPK3, IRS1, and PLCG2. These interactions underscore ROS1’s significant roles in cellular differentiation, growth, and morphology, as well as its importance in reproductive biology and cellular signaling.
| Product Name | Recombinant Human ROS1 Protein |
| Accession | P08922 |
| Host Species | Human |
| Gene | ROS1 |
| Source | Sf9 |
