This G-protein-coupled receptor binds sphingosine 1-phosphate (S1P), a bioactive lysosphingolipid, and is primarily associated with G(i) proteins. Its signaling activates RAC1, SRC, PTK2/FAK1, and MAP kinases, influencing cell migration by reorganizing the actin cytoskeleton and forming lamellipodia in response to sphingosine kinase SPHK1 activation. It is essential for normal chemotaxis toward S1P, embryonic heart development, and cardiac morphogenesis.
The receptor regulates sprouting angiogenesis and vascular maturation, inhibiting excessive sprouting during blood vessel formation. It facilitates the egress of mature T-cells from the thymus to the bloodstream and peripheral lymphoid organs. Additionally, it plays a role in osteoclast precursor migration, bone mineralization, and homeostasis.
In pulmonary endothelial cells, it mediates responses to oxidized phospholipids like 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, contributing to protection against ventilator-induced lung injury. This receptor’s roles in cardiovascular, immune, and skeletal systems underscore its importance in maintaining physiological balance.
| Product Name | Recombinant Human S1P1/EDG1 Protein |
| Accession | P21453 |
| Host Species | Human |
| Gene | S1PR1 |
| Source | Wheat germ |
