Recombinant Human Sodium/Glucose Cotransporter 2 (SLC5A2) Protein (His&Myc)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P31639
• Gene: SLC5A2
• CAT.NO: B000041
• Product Name: Recombinant Human Sodium/Glucose Cotransporter 2 (SLC5A2) Protein (His&Myc)
• Source: E.coli
• Protein Expression Range: 1-102aa
• Tag: N-10His&C-Myc
• Molecular Mass: 15.5kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

The electrogenic Na+^++-coupled sugar symporter actively transports D-glucose across the plasma membrane with a 1:1 Na+^++-to-sugar coupling ratio. Its activity is powered by the transmembrane Na+^++ electrochemical gradient maintained by the Na+^++/K+^++ pump. This symporter plays a crucial role in reabsorbing D-glucose from the glomerular filtrate in the kidney, specifically across the brush border of the early proximal tubules. By facilitating efficient glucose reabsorption, it supports glucose homeostasis and prevents its loss in urine, demonstrating its importance in renal function and overall metabolic regulation.