Recombinant Human Substance-P Receptor (TACR1) Protein (GST)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P25103
• Gene: TACR1
• CAT.NO: B000046
• Expression Systems: E.coli
• Product Name: Recombinant Human Substance-P Receptor (TACR1) Protein (GST)
• Protein Expression Range: 1-29aa
• Tag: N-GST
• Molecular Mass: 30.1kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

This receptor binds the tachykinin neuropeptide substance P and is likely coupled to G proteins that activate the phosphatidylinositol-calcium second messenger system. It plays a critical role in mediating the effects of substance P, which include regulating pain, inflammation, and stress responses. The receptor’s affinity for tachykinins follows the order: substance P > substance K > neuromedin-K, reflecting its primary role in substance P signaling. This receptor is involved in various physiological processes, including smooth muscle contraction, neurotransmission, and immune responses, making it a key target for therapeutic interventions in pain and inflammatory disorders.