Recombinant Human Synaptic vesicle glycoprotein 2A (SV2A), partial

• Purity: >85% (SDS-PAGE)
• Host Species: Homo sapiens (Human)
• Accession: Q7L0J3
• Gene: SV2A
• CAT.NO: B000253
• Expression Systems: E.coli In Vivo Biotinylation in E.coli Yeast Baculovirus Mammalian cell
• Product Name: Recombinant Human Synaptic vesicle glycoprotein 2A (SV2A), partial
• Source: E.coli;In Vivo Biotinylation in E.coli;Yeast;Baculovirus;Mammalian cell
• Tag: Tag type will be determined during the manufacturing process.
• Form: Lyophilized powder
• Buffer: Tris/PBS-based buffer, 6% Trehalose.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Alternative Names: KIAA0736; OTTHUMP00000014065; SV2; Sv2a; SV2A_HUMAN; Synaptic vesicle glycoprotein 2; Synaptic vesicle glycoprotein 2A; Synaptic vesicle protein 2a
• Protein Length: Partial
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Shelf Life: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.; Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

This protein plays a key role in controlling regulated secretion in neural and endocrine cells, selectively enhancing low-frequency neurotransmission. It positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles, which is crucial for efficient neurotransmitter release. As a receptor for Clostridium botulinum neurotoxin type A2 (BoNT/A2), it facilitates the toxin’s entry into cells, with glycosylation enhancing this interaction, though it is not essential. Additionally, it likely serves as a receptor for the closely related botulinum neurotoxin type A1 (BoNT/A1), contributing to the microbial infection process.