TEC is a non-receptor tyrosine kinase that acts as a versatile signal transducer, participating in multiple downstream pathways, including actin cytoskeleton regulation and immune signaling. It plays a redundant role with ITK in adaptive immune responses, supporting the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. TEC is crucial for TCR-dependent IL2 gene induction and phosphorylates CD28-specific substrate DOK1, contributing to CD28 signaling. It also mediates signals that suppress IL2RA expression upon TCR cross-linking.
TEC shares redundancy with BTK in BCR signaling, essential for B-cell development and activation by phosphorylating STAP1, a BCR-signaling protein. In mast cells, TEC supports cytokine production, while in myeloid cells, it facilitates growth and differentiation via activation by granulocyte colony-stimulating factor (CSF3). TEC participates in platelet signaling downstream of integrin activation and cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven FOS transcription. It also phosphorylates GRB10, a negative regulator of the FOS pathway.
In liver physiology, TEC promotes hepatocyte proliferation and regeneration via HGF-induced ERK signaling. It regulates unconventional secretion of FGF2 by phosphorylating Tyr-215 and may contribute to osteoclast differentiation. TEC integrates G protein-coupled receptor and integrin signaling in platelets, highlighting its broad role in immune, hematopoietic, and tissue regeneration processes.
| Product Name | Recombinant Human TEC Protein |
| Accession | P42680 |
| Host Species | Human |
| Gene | TEC |
| Source | Sf9 |
