The receptor for thrombopoietin (TPO) serves as a key regulator of megakaryopoiesis and platelet production, playing a central role in maintaining hematopoietic balance. It mediates the effects of TPO by promoting the proliferation and differentiation of megakaryocyte progenitor cells, leading to enhanced platelet formation. Additionally, it may function as a regulatory molecule involved in TPO-R-dependent immune responses, highlighting its potential role in modulating immune system activity. This receptor’s critical involvement in both hematopoiesis and immune regulation underscores its importance in physiological processes and its relevance as a target in therapeutic interventions for related disorders.
| Product Name | Recombinant Human Thrombopoietin Receptor (MPL) Protein (His) |
| Accession | P40238 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | MPL |
| Source | E.coli |
| Protein Expression Range | 26-491aa |
| Tag | N-6His |
| Molecular Mass | 56.5kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
