Recombinant Human Thyroid Hormone Receptor Beta (THRB) Protein (His-SUMO)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P10828
• Gene: THRB
• CAT.NO: B000217
• Expression Systems: E.coli
• Product Name: Recombinant Human Thyroid Hormone Receptor Beta (THRB) Protein (His-SUMO)
• Protein Expression Range: 1-461aa
• Tag: N-6His-SUMO
• Molecular Mass: 68.8kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.

A nuclear hormone receptor that functions as either a transcriptional repressor or activator, depending on the context. It has a high affinity for thyroid hormones, including triiodothyronine (T3) and thyroxine (T4). By binding these hormones, the receptor regulates the expression of target genes involved in various physiological processes, including metabolism, growth, and development. Its ability to modulate gene transcription plays a key role in maintaining hormonal balance and cellular function, highlighting its importance in the thyroid hormone signaling pathway.