The receptor tyrosine kinase NTRK1 plays a crucial role in the development and maturation of the central and peripheral nervous systems by regulating the proliferation, differentiation, and survival of sympathetic and sensory neurons. It acts as a high-affinity receptor for nerve growth factor (NGF), its primary ligand, and can also bind neurotrophin-3 (NTF3). However, NTF3 supports axonal extension through NTRK1 without influencing neuronal survival.
Upon binding dimeric NGF, NTRK1 undergoes homodimerization, autophosphorylation, and activation, recruiting and phosphorylating downstream effectors such as SHC1, FRS2, SH2B1, SH2B2, and PLCG1. These effectors mediate distinct but overlapping signaling pathways. Through SHC1 and FRS2, NTRK1 activates a GRB2-Ras-MAPK cascade, promoting cell differentiation and survival. PLCG1 activation regulates NF-kappa-B signaling, controlling the transcription of survival-related genes. Additionally, SHC1 and SH2B1 mediate a Ras-PI3 kinase-AKT1 cascade, further supporting cell survival.
In the absence of ligand binding and activation, NTRK1 may induce cell death, rendering neuronal survival dependent on trophic factor availability. This dual role highlights its importance in maintaining neuronal function and viability.
| Product Name | Recombinant Human TRKA Protein |
| Accession | P04629 |
| Host Species | Human |
| Gene | NTRK1 |
| Source | Sf9 |
