Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 4 (TNFSF4) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P23510
• Gene: TNFSF4
• CAT.NO: B000265
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Tumor Necrosis Factor Ligand Superfamily Member 4 (TNFSF4) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 51-183aa
• Tag: N-6His
• Molecular Mass: 16.3 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human OX40 in functional ELISA is less than 20 ug/ml.
• Research Area: Cancer
• Protein Length: Extracellular Domain

This cytokine binds to TNFRSF4 and plays a crucial role in co-stimulating T-cell proliferation and cytokine production. By interacting with TNFRSF4, it enhances T-cell activation and supports the immune response, promoting the expansion of T-cells and the release of various cytokines. This co-stimulation is essential for the proper functioning of the adaptive immune system, enabling T-cells to respond effectively to antigens. Through its influence on T-cell proliferation and cytokine secretion, this cytokine helps maintain immune system balance and facilitates robust immune responses during infection or immune challenges.