Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4) Protein (hFc), Active

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P43489
• Gene: TNFRSF4
• CAT.NO: B000252
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4) Protein (hFc), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 29-216aa
• Tag: C-hFc
• Molecular Mass: 46.8 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human TNFSF4 in functional ELISA is less than 10 ug/ml.
• Research Area: Cancer
• Protein Length: Partial

This receptor, for TNFSF4/OX40L/GP34, is a costimulatory molecule crucial for long-term T-cell immunity. It plays an essential role in enhancing T-cell activation, survival, and immune memory. Additionally, this receptor acts as a target for human herpesvirus 6B (HHV-6B), facilitating viral infection. Its involvement in both immune regulation and microbial infection highlights its dual role in immune response and susceptibility to viral pathogens. The receptor’s interactions contribute to the persistence of immune responses and the modulation of viral pathogenesis.