Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: P25942
• Gene: CD40
• CAT.NO: B000266
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 5 (CD40) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 21-193aa
• Tag: C-6His
• Molecular Mass: 20.2 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human TNFSF5 in functional ELISA is less than 100 ug/ml.
• Research Area: Immunology
• Protein Length: Extracellular Domain

This receptor binds TNFSF5/CD40LG and transduces signals mediated by TRAF6 and MAP3K8, activating ERK in macrophages and B cells. This signaling cascade leads to the induction of immunoglobulin secretion, playing a key role in the adaptive immune response. By activating ERK, it contributes to the regulation of immune cell functions, enhancing the production of antibodies by B cells and promoting immune responses. The receptor’s involvement in these signaling pathways underscores its importance in immune activation, particularly in the context of inflammation and immune system regulation.