Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 9 (TNFRSF9) Protein (His-hFc), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Homo sapiens (Human)
• Accession: Q07011
• Gene: TNFRSF9
• CAT.NO: B000276
• Expression Systems: Mammalian cell
• Product Name: Recombinant Human Tumor Necrosis Factor Receptor Superfamily Member 9 (TNFRSF9) Protein (His-hFc), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 24-186aa
• Tag: C-6His-hFc
• Molecular Mass: 44 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human TNFSF9 in functional ELISA is less than 50 ug/ml.
• Research Area: Cancer
• Protein Length: Extracellular Domain

This receptor binds TNFSF9/4-1BBL and transduces a signal that enhances CD8+ T-cell survival, cytotoxicity, and mitochondrial activity. By promoting these processes, it plays a probable role in boosting immunity against viruses and tumors. The receptor’s activation is critical for maintaining the function and longevity of CD8+ T-cells, which are essential for combating viral infections and tumor cells. This signaling pathway helps strengthen the immune response, supporting the body’s defense mechanisms against harmful pathogens and abnormal cell growth.