Recombinant Human Type-2 Angiotensin Ii Receptor (AGTR2) Protein (His-SUMO)

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Human
• Accession: P50052
• Gene: AGTR2
• CAT.NO: B000024
• Expression Systems: E.coli
• Product Name: Recombinant Human Type-2 Angiotensin Ii Receptor (AGTR2) Protein (His-SUMO)
• Protein Expression Range: 1-45aa
• Tag: N-6His-SUMO
• Molecular Mass: 20.8kDa
• Form: Liquid or Lyophilized powder
• Buffer: Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Storage: 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C.

This receptor binds angiotensin II, a vasoconstricting peptide involved in blood pressure regulation. Unlike traditional G-protein-coupled receptors, it signals primarily through non-canonical, G-protein- and beta-arrestin-independent pathways. It also interacts with MTUS1 to inhibit ERK2 activation, thereby suppressing cell proliferation. This unique signaling mechanism highlights its role in modulating vascular tone and cellular growth, offering potential therapeutic targets for conditions related to hypertension and abnormal cell proliferation.