This non-receptor tyrosine kinase is a key component of the IFN-alpha, IFN-beta, and IFN-gamma signaling pathways. It functions as a kinase partner for the interleukin-2 (IL-2) and interleukin-10 (IL-10) receptors, as well as the type I interferon receptor subunit IFNAR2. Upon interferon binding to the IFNAR1-IFNAR2 heterodimer, it phosphorylates and activates IFNAR2, generating docking sites for STAT proteins. This kinase directly phosphorylates STAT proteins, enabling their activation and nuclear translocation, while also promoting STAT signaling through transactivation of other JAK kinases associated with receptor complexes. Its essential role in cytokine signaling underscores its importance in immune response regulation and cellular communication.
| Product Name | Recombinant Human Tyrosine-Protein Kinase Jak1 (JAK1) Protein (His) |
| Accession | P23458 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Host Species | Human |
| Gene | JAK1 |
| Source | E.coli |
| Protein Expression Range | 850-1154aa |
| Tag | N-6His |
| Molecular Mass | 38.9kDa |
| Form | Liquid or Lyophilized powder |
| Buffer | Liquid form: default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
| Storage | 1. Store at -20¡«C/-80¡«C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4¡«C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20¡«C/-80¡«C. Protein in lyophilized powder form is stable for up to 12 months at -20¡«C/-80¡«C. |
