Recombinant Mouse Cytotoxic T-Lymphocyte Protein 4 (CTLA4) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Mus musculus (Mouse)
• Accession: P09793
• Gene: CTLA4
• CAT.NO: B000267
• Expression Systems: Mammalian cell
• Product Name: Recombinant Mouse Cytotoxic T-Lymphocyte Protein 4 (CTLA4) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 37-161aa
• Tag: C-6His
• Molecular Mass: 14.6 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 20 ng/ml.
• Research Area: Immunology
• Protein Length: Partial

CTLA4 is an inhibitory receptor that serves as a key negative regulator of T-cell responses. It binds to the B7 family ligands, CD80 and CD86, with significantly stronger affinity than the stimulatory coreceptor CD28, which also interacts with these ligands. This stronger binding allows CTLA4 to effectively dampen T-cell activation, thereby controlling immune responses and maintaining immune system balance. By inhibiting the signals that would otherwise activate T-cells, CTLA4 plays a crucial role in preventing excessive immune activation, which could lead to autoimmunity and tissue damage.