Recombinant Mouse Hepatitis A Virus Cellular Receptor 2 Homolog (HAVCR2) Protein (hFc), Active

• Purity: Greater than 90% as determined by SDS-PAGE.
• Host Species: Mus musculus (Mouse)
• Accession: Q8VIM0
• Gene: HAVCR2
• CAT.NO: B000248
• Expression Systems: Mammalian cell
• Product Name: Recombinant Mouse Hepatitis A Virus Cellular Receptor 2 Homolog (HAVCR2) Protein (hFc), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 20-191aa
• Tag: C-hFc
• Molecular Mass: 46.3 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Human Galectin 9 in functional ELISA is less than 20 ug/ml.
• Research Area: Immunology
• Protein Length: Extracellular Domain

This cell surface receptor plays a key role in regulating both innate and adaptive immune responses, with a generally recognized inhibitory function. However, some reports suggest that its activity may vary depending on the cellular context or the specific ligand. It regulates macrophage activation, inhibits Th1-mediated autoimmune and alloimmune responses, and promotes immunological tolerance. In CD8+ cells, it attenuates TCR-induced signaling by blocking NF-kappaB and NFAT activities, which reduces IL-2 secretion. This function may be linked to its association with LCK, affecting TCR subunit phosphorylation. Conversely, it can activate TCR signaling in T-cells, likely involving ZAP70, LCP2, LCK, and FYN.