Recombinant Mouse Leukocyte Surface Antigen Cd47 (CD47) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Mus musculus (Mouse)
• Accession: Q61735
• Gene: CD47
• CAT.NO: B000263
• Expression Systems: Mammalian cell
• Product Name: Recombinant Mouse Leukocyte Surface Antigen Cd47 (CD47) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 19-158aa
• Tag: C-6His
• Molecular Mass: 16.7 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use.; 2. Avoid repeated freeze-thaw cycles.; 3. Store working aliquots at 4°C for up to one week.; 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Mouse SIRPA in functional ELISA is less than 20 ug/ml.
• Research Area: Cancer
• Protein Length: Partial of Isoform 2

This adhesive protein mediates cell-to-cell interactions and acts as a receptor for thrombospondin (THBS1), modulating integrin signaling through heterotrimeric G protein activation. It plays roles in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation. It modulates pulmonary endothelin (EDN1) signaling and nitric oxide (NO) signaling, acting as a pressor agent to support blood pressure. Additionally, it influences memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it prevents dendritic cell maturation and cytokine production. It also enhances T-cell activation, modulates FAS-dependent apoptosis, and may suppress angiogenesis.