The catalytic subunit of the gamma-secretase complex is an intramembrane protease that cleaves integral membrane proteins, including Notch receptors and amyloid-beta precursor protein (APP). Its activity requires other gamma-secretase complex components and is critical for Notch and Wnt signaling. It regulates processes such as cytosolic CTNNB1 (beta-catenin) levels and downstream signaling pathways.
By interacting with CDH1 (E-cadherin), it promotes cell-cell adhesion, stabilizing complexes with CTNNB1, CTNND1, and JUP. During apoptosis or calcium influx, it cleaves CDH1, disassembling these complexes, increasing cytoplasmic CTNNB1, and negatively regulating Wnt signaling. This subunit is essential for embryonic brain and skeleton development, normal angiogenesis, and neurite outgrowth.
Additionally, it mediates the cleavage of EphB2/CTF1 to EphB2/CTF2 and functions as a calcium-leak channel, contributing to calcium homeostasis. It regulates presynaptic facilitation, spike transmission, and synaptic vesicle replenishment by controlling SYT7 expression, underscoring its role in neural function and signaling.
| Product Name | Recombinant Mouse SIGNR1 Protein (His Tag) |
| Accession | P49768 |
| Host Species | Mouse |
| Gene | PSEN1 |
| Source | HEK293 |
