Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4) Protein (His), Active

• Purity: Greater than 95% as determined by SDS-PAGE.
• Host Species: Mus musculus (Mouse)
• Accession: P47741
• Gene: TNFRSF4
• CAT.NO: B000264
• Expression Systems: Mammalian cell
• Product Name: Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4) Protein (His), Active
• Endotoxin: Less than 1.0 EU/μg as determined by LAL method.
• Protein Expression Range: 20-211aa
• Tag: C-6His
• Molecular Mass: 22.1 kDa
• Form: Lyophilized powder
• Buffer: Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
• Storage: 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
• Bioactivity: The ED50 as determined by its ability to bind Mouse TNFSF4 in functional ELISA is less than 50 ug/ml.
• Research Area: Cancer
• Protein Length: Extracellular Domain

This receptor, which binds TNFSF4/OX40L/GP34, serves as a costimulatory molecule crucial for long-term T-cell immunity. It plays a pivotal role in enhancing T-cell activation, survival, and the persistence of immune responses. Through its interactions with TNFSF4/OX40L, the receptor helps maintain immune memory, supporting the longevity and effectiveness of T-cell responses. This function is vital for sustaining immunity over time, particularly in adaptive immune responses. By modulating T-cell activity, it contributes to the immune system’s ability to respond to repeated infections or challenges, highlighting its importance in immune regulation and homeostasis.